Posted in Awards on May 21, 2018 at 10:06 am
Lipke Lab graduate researcher Yuan Tian was named recipient of the 2018 Alabama EPSCoR Graduate Research Scholars Program Fellowship! Congratulations!
Posted in Presentations on April 23, 2018 at 3:31 pm
We are very honored to have had the opportunity to share our research at SFB2018! Lipke Lab members were accepted to give 7 oral presentations and 3 poster presentations throughout the meeting!
Check out our Instagram for more information.
Posted in latest projects, Research on April 18, 2018 at 10:27 am
A recent publication in Scientific Reports from the Lipke and Arnold Labs at Auburn University titled “A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy” reports on using the SynVivo microfluidic platform to develop and validate a three dimensional in vitro breast cancer model with a tumor-mimetic microvascular network. The model recapitulates the in vivo heterogeneity in tumor perfusion and resulting differences in cellular morphology, growth and drug responses.
This significant body of work resulted from the collaboration of Dr. Lipke’s tissue engineering background with Dr. Arnold’s cancer biology and drug delivery expertise.
According to Dr. Lipke “ Replicating the pathophysiological architecture and non-uniform drug distribution of native vascularized breast tumors is critical for a realistic tumor model. SynVivo’s microvascular networks provided just the right environment to monitor the therapeutic circulation in the vasculature, transport across the vessel walls, and delivery to 3D tumors, which renders it ideally suited as a platform for performing cellular assays and drug screening”.
Dr. Arnold agrees and adds, ”The ability of these engineered cancer tissues for long-term culture, heterogeneous morphology and anti-cancer drug response provides a unique perspective to understand how nanomedicines may interact with various tumors. This will enable development of therapeutics with improved efficacy and minimal toxicity while improving patient outcomes, thereby providing an in vitro model analogous to the heterogeneity observed in vivo”.
This vascularized tumor model provides a necessary platform for investigation of cancer-stromal-endothelial interactions, tumor metastases, drug delivery and efficacy for both pre-clinical research and translational outcomes.
Download the full publication below
A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy
Pradhan et al (2018) 8:3171 | DOI:10.1038/s41598-018-21075-9
Posted in Awards, latest projects on March 30, 2018 at 11:04 am
Elizabeth Lipke, the Mary and John H. Sanders Associate Professor of chemical engineering, and Selen Cremaschi, the B. Redd Associate Professor of chemical engineering, were awarded a $621,934 grant from the National Science Foundation for their research on cardiac tissue manufacturing.
For more information: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1743445&HistoricalAwards=false
Posted in Research on March 29, 2018 at 11:24 pm
Dr. Elizabeth Lipke’s research on cancer models and drug testing is highlighted in Auburn University webpage:
Engineered model tumors look to advance cancer drug application
Posted in Presentations on March 29, 2018 at 10:22 pm
Lipke Lab members presented their research at the AU This is Research Student Symposium alongside nearly 500 Auburn student researchers!
Posted in Presentations on March 29, 2018 at 10:14 pm
Lab member Yuan attended and presented his research work at the 255th ACS National Meeting & Exposition in New Orleans, Louisiana. The title for his presentation was “Novel Microfluidic System for Encapsulation of Equine Endothelial Colony Forming Cells for Local Cell Delivery”.
Congratulations to Bryana, Luke, and Joshita for winning the Auburn Undergraduate Research Fellowship!
Posted in Awards, Undergraduates on March 29, 2018 at 10:04 pm
Posted in Awards, Outreach, Presentations on March 29, 2018 at 9:54 pm
Congratulations to Lipke Lab member Nicole Habbit who won first place at the Finish in Five competition! Nicole had to explain her research to a general engineering population in 5 minutes. #AuburnEngineering