Recent Publications

Due to copyright restrictions, we are unable to provide manuscripts online. Please refer to the journal websites email for an electronic reprint.


Yin, X.; Zhao, G.; Schneller, S.W. Carbocyclic Sinefungin. Tetrahedron Lett. 2007, 48, 4809-4811. doi:10.1016/j.tetlet.2007.05.079


Li, W.; Yin, X.; Schneller, S.W. 5′-Fluoro-5′-deoxyaristeromycin. Bioorg. Med. Chem. Lett. 2008, 18, 220-222. doi:10.1016/j.bmcl.2007.10.095


Zhou, J.; Yang, M.; Akdag, A.; Wang, H.; Schneller, S.W. Carbocyclic 4′-epi-Formycin. Tetrahedron 2008, 64, 433-438. doi:10.1016/j.tet.2007.10.054


Ye, W.; He, M.; Schneller, S.W. Synthesis of the 6′-Iso Analogs of Neplanocin and 5′-Homoneplanocin A. Tetrahedron Lett. 2009, 50, 7156-7158. doi:10.1016/j.tetlet.2009.10.016


Yin, X.q.; Li, W.-k.; Yang, M.; Schneller, S.W. A New Synthesis and an Antiviral Assessment of the 4′-Fluoro Derivative of 4′-Deoxy-5′-noraristeromycin. Bioorg. Med. Chem. 2009, 17, 3126-3129. doi:10.1016/j.bmc.2009.03.004


Gowen, B.B.; Wong, M.H.; Larson, D.; Ye, W.; Jung, K.-H.; Sefing, E.J.; Skirpstunas, R.; Smee, D.F.; Morrey, J.D.; Schneller, S.W. Development of a New Tacaribe Arenavirus Infection Model and Its Use to Explore Antiviral Activity of a Novel Aristeromycin Analog. PLoS One 2010, 5, e12760. doi:10.1371/journal.pone.0012760.


Daffis, Stephane; Szretter, Kristy J.; Schriewer, Jill; Li, Jianqing; Youn, Soonjeon; Errett, John; Lin, Tsai-Yu; Schneller, Stewart; Zust, Roland; Dong, Hongping; Thiel, Volker; Sen, Ganes C.; Fensterl, Volker; Klimstra, William B.; Pierson, Theodore C.; Buller, R. Mark; Gale Jr, Michael; Shi, Pei-Yong; Diamond, Michael S. 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 2010, 468(7322), 452-456.doi:10.1038/nature09489.


Liu, C.; Chen, Q.; Schneller, S.W. (+)-Neplanocin F, 2′-Fluoroneplanocin, and a 6′-isoneplanocin via a common versatile cyclopentenol precursor. Tetrahedron Lett. 2011, 52, 4931-4933. doi.10.1016/j.tetlet.2011.07.059


Li, W.; Ye, W.; Schneller, S.W. 6′-Oxa analogs of S-adenosylhomocysteine, Tetrahedron, 2012, 68, 65-71. doi.10.1016/j.tet.2011.10.063


Zhang, Y.; Ye, W.; Wang, H.; Schneller, S.W. Carbocyclic 4-deazaformycins. Synthesis, 2012, 44, 723-730. doi.10.1055/s-0031-1289688


Chen, C.; Ye, W.; Liu, C.; Schneller, S.W. 2’-Fluoro-3-deazaaristeromycin. Tetrahedron, 2012, 68, 3908-3914. doi:10.1016/j.tet.2012.03.023.


Liu, C.; Chen, Qi.; Schneller. S.W. 3-Bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin: Synthesis and antiviral activity. Bioorg. Med. Chem Letters 2012, 22, 5182-5184.


Gu, L.; Musiienko, V.; Bai, Z.; Qin, A.; Schneller, S.W.; Li, Q. Novel virostatic agents against bluetongue virus. PLOS One 2012, 7 (8), e43341.


Chen, C.; Ye, W.; Schneller, S.W. A convenient synthesis of the L-like enantiomer of 4′-methyl-3-deazaaristeromycin, Heterocycles 2012, 86, 697-704 (invited paper for issue honoring Professor Ei-ichi Negishi, 2010 Nobel Laureate in chemistry for his research in palladium catalyzed cross couplings in organic synthesis; shared with Richard Heck and Akira Suzuki).


Liu, C.; Chen, Q.; Yang, M.; Schneller, S.W. C-3 Halo and 3-methyl substituted 5’-nor-3-deazaaristeromycins: Synthesis and antiviral properties. Bioorg. Med. Chem. 2013, 21, 359-364.


Yang, M; Wei, Y; Schneller, S.W. 6’-Methyl-5’-homoaristeromycin: A structural variation of the anti-orthopox virus candidate 5’-homoaristeromycin. Bioorg. Med. Chem. 2013, 21, 4374-4377.

Sefing, E.J.; Wong, M.; Larson, D.P.; Hurst, B.L.; Van Wettere, A.J.; Schneller, S.W.; Gowen, B.B. Vascular leak ensues a vigorous proinflammatory cytokine response to Tacaribe arenavirus infection in AG129 mice. Virol. J. 2013, 10, 221-233.


Gu, L., Schneller, S. W., Li, Q. Assays for the Identification of Novel Antivirals against Bluetongue Virus. J. Vis. Exp. (80), e50820, doi:10.3791/50820 (2013).


Chen, Q.; Liu, C.; Shulyak, T.S.; Schneller, S.W. The metathesis reaction for side chain construction in carbocyclic sinefungin analogue synthesis. Tetrahedron 2014, 70, 892-900.


Das, S.R.; Schneller, S.W. The 5′-Nor Aristeromycin Analogues of 5′-Deoxy-5′ methylthioadenosine and 5′-Deoxy-5′-thiophenyladenosine. Nucleosides Nucleotides Nucleic Acids. 2014, 33, 668-677.


Ye, W.; Schneller, S.W. The enantiomers of the 1′,6′-isomer of neplanocin A: Synthesis and antiviral properties. Bioorg. Med. Chem. 2014, 22, 5315-5318.


Chen, Q.; Liu, C.; Komazin, G.; Bowlin, T.; Schneller, S.W. Synthesis and antiviral activities of 3-deaza-3-fluoroaristeromycin and its 5’ analogues. Bioorg. Med. Chem. 2014, 22, 6961-6964.


Ye, W.; Schneller, S.W. 5′-Noraristeromycin C-nucleosides based on imidazo[1,2-a]pyrazine. Synthesis 2015, 47, 228-234.


Wang, H.; Zhang,Y.; Ye, W.; Schneller, S.W. Preparation of 8-aza-7-deazaaristeromycin and -neplanocin A and their 5′-homologs. J. Heterocycl. Chem. 2015, 52, 1132-1135.


Liu, C.; Chen, Q.; Gorden, J.D.; Schneller, S.W. 2- and 3-Fluoro-3-deazaneplanocins, 2-fluoro-3-deazaaristeromycins, and 3-methyl 3-deazaneplanocin: synthesis and antiviral properties. Bioorg. Med. Chem. 2015, 23, 5496-5501.


Liu, C.; Chen, Q.; Schneller, S.W. Enantiomeric 3-deaza-1′,6′-isoneplanocin and its 3-bromo analogue: Synthesis by the Ullmann reaction and their antiviral properties. Bioorg. Med. Chem. Letters 2016. Available online 19 Dec 2015.


Ye, W.; Schneller, S.W. The synthesis of both diastereomers of 5′-methylhomoaristeromycin. Nucleosides Nucleotides Nucleic Acids 2016, 35, 105-113. DOI: 10.1080/15257770.2015.1114131


Yin, X.; Chen, Q.; Ye, W.; Liu C.; Schneller, S.W. 8-Methyl derivatives of aristeromycin, neplanocin, 3-deazaneplanocin and related analogs. Heterocyles, 2017, 95, 445-461. DOI: 10.3987/COM-16-S(S)36. Invited paper for special issue to honor Dr. Masakatsu Shibasaki on the occasion of his 70th birthday.


Yin, X.; Schneller, S.W. 3,7-Dideazaneplanocin: synthesis and antiviral analysis, Antiviral Chem. Chemother. 2017, 25, 90-93.


Liu, C.; Chen, Q.; Schneller, S.W. Both enantiomers of 6′-isoneplanocin. Nucleosides Nucleotides Nucleic Acids 2017, 36, 631-636.


Chen, Q.; Liu C.; Bowlin, T.L.; Schneller S.W. 5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties. Bioorg. Med. Chem. Lett. 2018, 28, 1456-1458


Liu, C., Chen, Q., Cardinale, S., Bowlin, T.L., Schneller, S.W., 6′-Fluoro-3- deazaneplanocin: synthesis and antiviral properties, including Ebola, Bioorg. Med. Chem. Lett. (2018), doi:


Liu, C.; Chen, Q.; Schneller. S.W. Synthesis of D-like and L-like 5′-fluoro-5′-deoxy-1′, 6′-isoneplanocins and their antiviral activity including Ebola,acceptedNucleosides, Nucleotides Nucleic Acids


Liu, C.; Coleman, R.; Archer, A.; Hussein, I.; Bowlin, T.L.; Chen, Q.; Schneller, S.W. Enantiomeric 4′-Truncated 3-deaza-1′,6′-isoneplanocins: synthesis and antiviral properties including Ebola. acceptedBioorg. Med. Chem. Lett. and asap link is